![]() Where PCC is unavailable and emergency reversal is required, FFP should be used, along with Vitamin K to sustain the reversal effect.Not routinely used to reverse warfarin anticoagulation.The suggested dose of Prothrombinex-VF ranges from 15-50 IU/kg and is based on bleeding risk as outlined in the Guidelines for the management of an elevated INR in adults.Prothrombinex-VF is able to completely reverse a supratherapeutic INR within 15 minutes however, vitamin K is also required to sustain the reversal effect as the half-lives of the infused clotting factors are similar to endogenous factors.PCCs are reconstituted into a small volume for rapid infusion and have a fast onset of action.Prothrombinex-VF is a coagulation factor concentrate containing factors II, IX and X and a small amount of factor VII.Prothrombin complex concentrate (PCC) e.g.See the Guidelines for the management of an elevated INR in adults for details. Dosage of Vitamin K varies between 0.5 mg and 10 mg based on bleeding or risk of bleeding.Vitamin K should not be administered by subcutaneous or intramuscular routes.IV has a more rapid response, within 6-8 hours. Both oral and intravenous (IV) routes are effective in reducing a raised INR due to warfarin with a similar correction of INR by 24 hrs.Vitamin K is a safe and effective antidote to warfarin. ![]() If the INR is only minimally above the therapeutic range (up to 10%) dose reduction is generally not necessary.Resume therapy at a lower warfarin dose when the INR approaches therapeutic range. ![]()
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